Supplements

Question 1

According to St. John Wort, supplements are used to benefit what?

Answer 1

mild to moderate depression

Question 2

Mechanism of supplements?

Answer 2

inhibits metabolism and reuptake of serotonin, dopamine, and epinephrine

Question 3

According to St. John Wort, are supplements more effective than placebo for mild to moderate depression?

Answer 3

NO

Question 4

Limitations to supplements?

Answer 4

• short duration
• did not use DSM criteria
• variable doses used
• comparative doses of Rx antidepressants were typically subtherapeutic
• associated with allergic reactions and photosensitization; no evidence for efficacy
• drug interactions do exist - strong inducer of CYP and p-glycoprotein

Question 5

Are herbs and supplements regulated by any governing body?

Answer 5

NO

Question 6

Garlic supplements potentially inhibit what?

Answer 6

cholesterol synthesis

Question 7

Garlic supplements effect what?

Answer 7

plasma protein and cell membrane remodeling

Question 8

What other activity/ability is possible of garlic supplements?

Answer 8

• lipid-lowering ability
• anti-hypertensive effect
• lower LDL’s
• antiplatelet, antithrombotic, and fibrinolytic activity

Question 9

Reasons for recommending garlic supplements?

Answer 9

• probably safe
• inexpensive
• few side effects
• must use high doses

Question 10

Glucosamine: metabolized where? incorporated into what? distributed where?

Answer 10

metabolized in the liver, incorporated into plasma proteins, distributed in liver/kidneys/articular cartilage

Question 11

Where is chondroitin distributed?

Answer 11

into various tissues, primarily cartilage

Question 12

Exogenuos glucosamine distributes where and increases the synthesis of what?

Answer 12

distributed to joints (knees) and increases the synthesis of hyaluronic acid

Question 13

Was there a benefit seen relative to placebo in short term treatment with glucosamine chondroitin sulfate?

Answer 13

NO

Question 14

Is there a benefit for short term treatment in patients with moderate to severe OA?

Answer 14

YES