Pharmaceutics > Suppositories + Inserts > Flashcards

Suppositories + Inserts Flashcards

(45 cards)

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1
Q

What is a suppository?

A

Solid dosage form inserted into body orifices where they melt, soften, or dissolve at body temperature

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2
Q

Supossitories delivery is ______ dependent

A

formulation

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3
Q

Rectal suppositories are generally used for ______ delivery

A

systemic

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4
Q

Rectal suppositores are generally used to treat _____ anorectal diseases

A

local

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5
Q

What are the disadvantages of rectal suppositories?

A
  1. Violates patient’s dignity
  2. Local irritation
  3. Available in limited strengths
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6
Q

What are the advantages of rectal administration over oral?

A
  1. Administration is simple
  2. Avoids hepatic first pass elimination
  3. Drugs stability (avoids degradation in GI)
  4. Avoids unpleasant taste
  5. Kids + ppl unable to use PO meds can get it
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7
Q

What are some limitations of rectal administration?

A
  1. Pt acceptablity/compliance is poor especially for chronic therapy
  2. Limited commercial doses available
  3. Variable effectiveness
  4. Suppository may be rejected/ascend post insertion
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8
Q

Weight of rectal suppositories dependent upon ____ of the drug + base (mainly)

A

density

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9
Q

Vaginal suppositories are also known as….?

A

Pessaries

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10
Q

What are the advantages of vaginal administration of RX?

A
  1. Local + systemic delivery
  2. Large surface area
  3. Avoids hepatic first pass + GI degradation
  4. Self administration/removal is often an option
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11
Q

What are some limitations of vaginal administration?

A
  1. Route is gender specific
  2. Menstrual cycle/hormonal variations
  3. Physiological pH may enhance or affect dissolution and absorption of drugs
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12
Q

Urethral suppositories are also known as…?

A

Bougies

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13
Q

Systemic absorption is more commonly seen with _____ rather than vagina delivery

A

rectal

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14
Q

What are some formulation variables?

A
  1. Form of active
  2. Solubility
  3. Viscosity
  4. Brittleness
  5. Volume contraction
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15
Q

Generally, drug form will (be/not be) altered by rectal environment

A

not be

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16
Q

Rectal fluid is generally in pH range of 7.2-7.4 w/ _______ buffer capacity

A

negligible

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17
Q

Greater absorption is expected with a/an _____ colon

A

empty

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18
Q

What is brittleness caused by?

A
  1. High solid concentration

2. Shock cooling

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19
Q

Lipophilic drugs in fatty base have a (higher/lower) tendency to be released to the surround aqueous fluids than a ______ drug in a fatty base

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A

lower + hydrophilic

20
Q

Suppository base should remain ____ at room temperature

21
Q

What is the most commonly used fatty (oleaginous) base?

22
Q

What is the most important characteristic of fatty (oleaginous) base?

Study These Flashcards
A

Melts quickly at body temperature

23
Q

How is cocoa butter harvested?

Study These Flashcards
A

Seed of Theobroma cacao

24
Q

What are some advantages of fatty (oleaginous) bases?

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A
  1. Softens at 30 degrees C
  2. Generally non-irritating
  3. Acts as an emollient
25
What are some disadvantages of fatty (oleaginous) bases?
1. Poor/eratic release of some drugs 2. Exhibits polymorphism (in cocoa butter) 3. May leak
26
Water-soluble bases ______ and mixes w/ aqueous body fluids
dissolves
27
Water-soluble bases may cause some _____ due to uptake of water and cause a slight ______ of the mucosa
irritation + dehyrdation
28
What is the most popular water-soluble base?
PEGS
29
What is an advantage of PEG?
1. Mix and match MW bases to attain specific MP
30
What is a disadvantage of PEG?
1. Drug incompatibilities | 2. Cause irritation
31
Glycerinated gelatin suppositories (are/are not) recommended for rectal use but is more useful as a/an _____ insert
are not + vaginal
32
What is wrong with using glycerinated gelatin suppositories?
1. Osmotic effect | 2. Defecation reflex
33
Glycerinated gelatin bases provides (faster/slower) release and has a tendency to (absorb/repel) mositure
slower + absorb
34
What should you protect glycerinated gelatin bases from?
Atmospheric mositure
35
PEG suppositories (do/do not) melt at body temperature
do not
36
PEG suppositories contribute to ______ release of drugs
prolonged
37
PEG mixes w/ mucous upon dissolving and as a result it has ____ leakage compared to fatty bases
less
38
Slow release; poor escaping tendency A. Oil-soluble drug + base B. Water-soluble drug + fatty base C. Oil-soluble drug + water base D. Water-soluble drug + base
A. Oil-soluble drug + base
39
Moderate release A. Oil-soluble drug + base B. Water-soluble drug + fatty base C. Oil-soluble drug + water base D. Water-soluble drug + base
C. Oil-soluble drug + water base
40
Moderate release; based upon diffusion; all water soluble A. Oil-soluble drug + base B. Water-soluble drug + fatty base C. Oil-soluble drug + water base D. Water-soluble drug + base
D. Water-soluble drug + base
41
Rapid release A. Oil-soluble drug + base B. Water-soluble drug + fatty base C. Oil-soluble drug + water base D. Water-soluble drug + base
B. Water-soluble drug + fatty base
42
What are the methods of suppository prep?
1. Molding from a melt (most common) | 2. Hand rolling/shaping
43
Suppository drug must be released within _____
6 hours
44
To ensure max drug release, apply principle of _____ ______
opposite characteristics
45
Release of drug and onset of drug action depends upon three factors...what are they?
1. Liquefaction of base 2. Dissolution of active 3. Drug diffusion thru tissues
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