Suppository Calculations

Question 1

When is Witepsol 75 used as a base?

Answer 1

*drug is a liquid
*drug is soluble in base

Question 2

What is the general calculation for suppository base?

Answer 2

Amount of base= theoretical amount-displaced amount
Theoretical is no. of suppositories x size
Displaced is amount of drug/DV

Question 3

When does DV=1?

Answer 3

When liquid trituration needed

Question 4

When is liquid trituration needed?

Answer 4

When amount of drug <50 mg