SWS

Question 1

Increased SWS

Answer 1

Gabapentin

Olanzapine via 5HT2A and 5HT2C receptor antagonism

Risperidone (binds D1/D2/5HT2/alpha 1/H1/5HT1A)

Thioridazine (D1/D2/alpha 1. H1)

Ziprasidone (D1/D2/5HT2. musc acetycholine, alpha 1, H1,5HT1A)

NOT Clozapine (lower affinity 5HT2,musc acetychol, alpha1, H1)

Low dose cannabis as well as decreases REM sleep

Antihistamines

Alcohol

Benztropine

Carbamazepine

Clonidine Decreases REM sleep also)

Lithium

Mirtazapine

Trazodone

Phenytoin

Question 2

Decreased SWS

Answer 2

Fluoxetine

Clonazepam (and decreases REM)

Methadone (decreases REm also)

High dose of Cannabis

Caffeine
Heroine (opiate)

Amphetamine (increases NE,Dop,Ser by increasing releae and inhibiting uptaek)- methylphenidate

Cocaine (stimulant that blocks Ser, NE,

Dop reuptake, sodium channel blocker)

Dexamethasone (also REM sleep)