Systemic Antibiotics

Question 1

Need info from slide

Answer 1

1-25

Question 2

Metronidazole is

Answer 2

bacteriocidal aganst anaerobic bacteria

Question 3

Metronidazole inhibits

Answer 3

DNA synthesis

Question 4

Metronidazole in DNA replication does

Answer 4

inserts itself in the double strand

Question 5

Metronidazole is used alone or with other ant.?

Answer 5

can be used alone but most of the time with other ant.

Question 6

Metronidazole used with

Answer 6

PCN

Question 7

Metronidazole is ineffective alone against

Answer 7

A.A.

Question 8

side effects of Metronidazole

Answer 8

antabuse type reaction
metallic taste
orange urine
Nausea and vomiting
peripheral neuropathy (infrequent)

Question 9

Clindamycin is used when

Answer 9

PCN doesnt work/allergices

Question 10

Clindamycin is good

Answer 10

anaerobic coverage
inhibits protein systhesis
bacteriostatic

Question 11

Clindamycin side effects

Answer 11

risk of pseudomembranous colitis due to growth of clostridium difficile, skin rash

Question 12

Azithromycin is

Answer 12

• effective against anaerobes and gram neg bacilli
• penetrates fibroblastsand phagocytes
• concentration are sig higher in periodontallesions compared to normal gingiva

Question 13

if systemic antimicrobials are indicated as part of periodontal therapy, they should be_____ to mechanical debridement.

Answer 13

adjunctive

Question 14

there is____ to recommend a specific protocol for the use of adj. systemic antimicrobial with nonsurgival mech debridement

Answer 14

no direct evidence

Question 15

there is ____ that antibiotitcs in take should start on the day the debriment completion, debridement should be completed within a ___

Answer 15

indirect evidence, short time (

Question 16

drugs that modulate host respnse

Answer 16

• non steroidal anti inflammatory drugs (NSAIDS)

- subantimicrobial dose of doxyclyclinse (Periostat)

Question 17

periostate significance

Answer 17

• way below dose used for infectinos
• the mech is for anticollagenase activity alone, inhibiting protein synthesis in bacteria cells
• min risk of bacterial resistance to tetracyclines

Question 18

chemotherapeutic agents is a term

Answer 18

for a chemical substance that provides clinical therapeutic benifits

Question 19

clinical benifits of chemotherapeutic agents

Answer 19

• antimicrobial actions

- ability to increase the host’s resistance.

Question 20

in systemic antibiotics, there is

Answer 20

No evidence that antibiotics alone can arrest

periodontal disease.

Question 21

in systemic antibiotics, the Greatest benefit in :

Answer 21

• the presence of systemic disease
• immunocompromised patients
• aggressive forms of periodontal disease
• patients who are not good candidates for more complex and invasive treatment

Question 22

Chronic periodontitis can and should be treated initially ______ systemic antibiotics.

Answer 22

without

Question 23

The clinical diagnosis and situation dictate theneed for possible antibiotic therapy as an adjunct in controlling __________.

Answer 23

active periodontal disease.

Question 24

Periodontal disease is predominately a gram _____ anaerobic infection

Answer 24

negative

Question 25

When should you consider the use of systemic antibiotics during periodontal therapy?

Answer 25

- Aggressive periodontitis - Necrotizing ulcerative periodontal disease - “Refractory Periodontitis” or patients who are considered to be high risk - Generalized severe chronic periodontitis - Periodontal patients who are immunocompromised - Heavy smokers - In conjunction with certain surgical procedures (implants, bone grafting, sinus lifts, Guided tissue regeneration)

Question 26

Penicillians MOA, spectrum, effect

Answer 26

Inhibits cell wall syn, narrow, bacteriocidal

Question 27

Frequently used penicillins (PCNs) in periodontal therapy include

Answer 27

- Amoxicillin - Pen VK - Amoxicillin with clavulanic acid Augmentin)

Question 28

Tetrcyclines moa, spectrum and effect

Answer 28

inhibits protein synthesis, broad, bacteriostatic

Question 29

Tetrcyclines indications

Answer 29

- “Refractory” Periodontitis | - Aggressive Periodontitis (EOP)

Question 30

Tetrcyclines advantages

Answer 30

-Ability to concentrate in the tissues and destroy A.a. -Anticollagenase activity

Question 31

tetrcyclines contraindications

Answer 31

- dont give with milk/dairy, Fe containing vitamins and minerals orantacids - photosensitivity - avoid use in children, preg/nurs (may cause discoloration of teeth)

Question 32

forms of tetracyclines used in perio

Answer 32

doxycyline | minocycline

Question 33

doxycyline is _____ on the stomach than mino. and tetr.

Answer 33

eaiser

Question 34

can you take dairy with doxycyline

Answer 34

yes