T-cell Surface Molecules

Question 1

CD4

Answer 1

1. binds MHC class 2 on APC

2. signal transduction

Question 2

CD8

Answer 2

1. Binds MHC 1 on APC

2. Signal transduction

Question 3

LFA

Answer 3

1. binds ICAM on APC, endothelium

2. adhesion of cell

Question 4

CTLA 4

Answer 4

1. binds CD80 with higher affinity on APC

2. inhibition

Question 5

PD-1

Answer 5

1. binds PDL1-2 on APC and tumor cells

2. inhibition

Question 6

CD28

Answer 6

1. Binds CD80 (B7) on APC ‘

2. co-stimulation

Question 7

CD3

Answer 7

1. no binding

2. signal transduction of TCR

Question 8

Which receptors are present on NAIVE T cells

Answer 8

1. LFA
2. L- selectin
3. CCR7

Question 9

T cell activation triggers a cascade producing the following (4)

Answer 9

1. ^^ CD40 L
2. ^^ IL-2
3. ^^ CD25 = IL2 receptor
4. ^^^ DNA synthesis for T cell cloning

Question 10

What cytokines activate T regulatory cells

Answer 10

IL2 and TGF B

Question 11

T regulatory cells express?

What is its transcription Factor?

Answer 11

CTLA-4 and CD25

Fox P3

Question 12

What do T regulatory cells secrete?

Answer 12

IL10 and TNF B