Tablets

Question 1

What are the three routes of tablet preparation?

Answer 1

Direct compression, wet granulation, dry granules.

Question 2

What are the steps to make a tablet using direction compression?

Answer 2

Dispense, mill, blend, tablet, coat.

Question 3

What are the steps to making a tablet using wet granulation?

Answer 3

Dispense, mill, blend, wet granulate, dry, tablet, coat.

Question 4

What are the steps to making a tablet using dry granulation?

Answer 4

Dispense, mill, blend, dry granulate, tablet, coat.

Question 5

What is the CARR index for an adequately compressible drug?

Answer 5

15-25%.

Question 6

What is the purpose of the main compression roll?

Answer 6

Form non-bonded interactions.

Question 7

What is the purpose of the pre compression roll?

Answer 7

Remove bulk of air.

Question 8

What are the two types of tablet formulation defects?

Answer 8

Capping, picking and sticking.

Question 9

What is capping?

Answer 9

Trapped air pockets, insufficient boundary lubricant, elastic recovery of one or more components.

Question 10

What is picking and sticking?

Answer 10

Material adheres to punch faces during tableting, important for embossed/engraved tooling, over articulated embossing.