TDM

Question 1

phenytoin target levels

Answer 1

10-20mg/l

Question 2

dose of phenytoin

Answer 2

LD: 15-20mg/kg in 3 doses
MD: 4-6mg/kg in 2-4 divided doses

Question 3

when to draw the levels of phenytoin

Answer 3

IV 2h after dose
PO 24h after
trough: 1h before morn dose

maintenance every 7d

Question 4

valproate target levels

Answer 4

50-100mg/L

Question 5

doses of valproate

Answer 5

LD: 20-30mg/kg
MD: 10-15mg/kg

Question 6

when to draw valproate doses

Answer 6

2-3d after LD , 3-5d after MD

Question 7

carbamazepine target levels

Answer 7

4-12mg/L

Question 8

dose for carbamazepine

Answer 8

100-200mg/d

Question 9

when to draw trough for carbamazepine

Answer 9

2weeks

Question 10

phenobarbital levels

Answer 10

10-30mg/L

Question 11

dose for phenobarbital

Answer 11

LD: 15-20mg/kg
MD: 10mg/h IV, 2mg/kg/d PO

Question 12

when to draw levels for phenobartial

Answer 12

2-3h post infusion then 3-4d
if MD 2wks