What is Epistasis
Effects of an allele from one gene, masking the effects of another gene.
Recessive epistasis
When a recessive phenotype at one locus renders the function of another gene at another locus ineffective.
Example of recessive epistasis and why it works the way it does:
Labrador retrievers come in 3 colors: choco brown, black, and yellow. This is due to the synthesis and deposition of 2 pigments Eumelanin and Pheomelanin.
When at locus one, the genotype is EE/Ee and at locus 2 the geno is BB/Bb, there is a black colour.
When the genotype is EE, Ee at locus one, eumelanin gets synthesized, and if at locus two the protein b is bb, then there is a brown color.
When the genotype is ee, no eumelanin gets synthesized and pheomelanin takes over and the labrador is yellow, regardless of what geno is at gene B.
Eumelanin
Produces darker pigment color, black/brown.
Genotypes: EE/Ee/ee
Pheomelanin
Produces lighter pigment colour, yellow.
Genotypes: BB/Bb/bb
Recessive epistasis ratios
9:3:4 (last 3 r yellow B-ee, and 1 bbee)
Dominant epistasis
When a dominant allele at one locus masks the function of an allele at another locus.
Summer Squash
Gene A involved in catalyzing a reaction between green and yellow pigment.
Gene B involved in deposition.
When geno at A is AA/Aa, enzyme A converts green pigment to yellow, and if protein b has bb, then the pigment gets deposited.
When geno at A is aa, no coversion and green pigment gets deposited.
When there is BB/Bb at the second locus, no matter if u have AA/Aa/aa, the pigment doesn’t get deposited and the squash is white
Dominant epistasis ratios
12 (white):3(yellow):1(green)
Complementary Gene Interaction
P and C are required for purple color. Both cominant alleles have to be present at the same time for genotype to be expression.
Complementary gene interaction ratios
9:7
Dominant supression
Dominant allele at one gene specifically supresses the dominant allele of another gene.
L allele allows blue pigment, D allele suppresses it.
Dominant suppression ratios
13:3