UC patients are at an increased risk for ____CA?
Colorectal CA
Risk is proportional to the extent and duration of disease
Risk increases with superimposed PSC
When considering Tx for PNA, when should you add Prednisone?
PaO2 35
MC opportunistic infection in AIDS and at what CD4 count?
PCP PNA
MC at CD4
1st line for PCP PNA?
PO TMP-SMX for non-acutely ill
IV TMP-SMX for the acutely ill
S/Sx of anserine bursitis
- sharp, well localized pain over anteromedial tibia
- pain present overnight (knees on top of each other when laying on side)
- negative valgus stress test
- normal Xray
- Treatment: RICE, cortisone injection
Causes of Anserine Bursitis
- Abnormal Gait
- Overuse
- Trauma
Anserine Bursa: location
Anteromedial over tibial plateau just below joint line of the knee
CJDx
Spongiform Encephalopathy caused by prion dx
- Rapidly progressive Dementia
- Myoclonus
- Sharp, triphasic, synchronous EEG
- Death in 6mos-1year of Sx onset
Huntington’s Dementia
ADDx, Huntington gene, Chromosome 4 - causes degeneration of the striatum Classic features: - Early dementia (35-50y/o) - Progressive choreiform movements of all limbs - Grimacing - Ataxic Gait
Parkinson’s Disease
Progressive loss of Nigrostriatal DA Neurons
Classical Features:
- Bradykinesia
- Resting Tremor that gets better with intentional movement
- Cogwheel rigidity
- Classic Shuffling gait
- Masked facies
Alzheimer’s Disease
Neurodegenerative Disorder
- Amyloid Plaques
- Neurofibrillary Tangles
- Selective loss of Cholinergic neurons
Pick’s Disease (Frontotemporal Dementia)
Degeneration of Frontal and Temporal Lobes
- Resembles ADx
- MC Females
- Onset of Sx: 50 y/o
- Personality + Language Changes are more prominent than cognitive Sx, which differentiates it from ADx
MC metastatic CA to the spine
Lung
Breast
Prostate
Multiple Myeloma
MC location for metastatic CA
Thoracic Spine [60%]
Lumbar Spine [30%]
S/Sx of Epidural Spinal Cord Compression (ESCC)
- Progressively worsening focal back pain with focal point tenderness
- UMN signs below level of lesions
- Sensory level present
Late Findings: paraplegia, Bowel/Bladder dysfunction
