Four polypeptide chain?
2 Alpha 2 Beta
one gram of Hb can combine with?
1.34 mL of oxygen
Hb saturation with O2 is a function of the PO2 and the ___________ of the oxyhemoglobin curve
Hb saturation with O2 is a function of the PO2 and the shape and position of the oxyhemoglobin curve.
Factors Shifting Curve to the left
- _
- _
- _
- _, _, _, and ____
- _
- _
- _
- Alkalosis
- Hypothermia
- Decreased 2,3-DPG
- Hypocarbia
- Fetal Hb, methemoglobin, carboxyhemoglobin and other abnormal Hbs
- Polycythemia
- Stored blood
Factors Shifting Curve to the right
- _
- _
- _
- _
- _
- _
- _
- Acidosis
- Hyperthermia
- Hypercarbia
- Increased 2.3-DPG
- Anemia
- Hypoxemia
- Abnormal Hbs
2,3-DPG
- organic phosphate in RBC
- end product of glucose metabolism
- binds with hb, decreasing Hbs affinity for oxygen
What does a left shift mean??
Greater affinity of Hb for oxygen. The SO2 will be higher than expected for a given PO2. (The P50 will be lower)
What does right shift of the curve mean?
there is less affinty of Hb for oxygen. The SO2 will be lower than expected for a given PO2 (The P50 will be higher)
HBS
Sickle Cell (Africa) - Malaria Protection
Fetal HB
has 2 alpha and 2 gamma chains
**Drug induced HbF to Tx sickle cell anemia**
