Rivastigmine(Exelon)
tacrine(Cognex)
potential for hepatic toxicity, rarely used because of side effects
donepezil(Aricept)
– it requires only once-per-day dosing.
– Enhances cholinergic function by the reversible inhibition of the hydrolysis of Ach by AChE.
– Slows progression
– Effective when cholinergic neurons are intact.
– May produce gastrointestinal side effects by inhibiting AChE in the periphery
Glantamine (Razadyne)
Memantine (Namanda)
Kubler Ross (5 Stages)
Stages of Grief
Chronic Sorrow
Primary (Irreversable) Dementia
Alzeimer’s Disease, Vascular Dementia, Picks Disease, Huntington’s Disease
Parkinson’s Dementia, Creutzfeidt-Jakob disease
Dementia: Reversible (secondary)
Delirium, Depression, Amnestic disorders, Tumors, Infection, Trauma, Some cerebral emboli
Recent memory loss but keeps long term memory
Stage 1: Mild (2-4 years)
Stage 1: Mild (2-4 years)
Inability to find words and the use of inappropriate words
Stage 1: Mild (2-4 years)
Neologism – invented and meaningless words
Stage 1: Mild (2-4 years)
Show signs of personality changes
Stage 1: Mild (2-4 years)
They are self awareness of loss that many patients suffer profound depression
Stage 1: Mild (2-4 years)
Intellectual decline continues to increase and includes amnesia, disorientation, apriaxia, aphasia, and depression
Stage 2: Moderate (2-10 years)
Lead to the loss of the ability to care for oneself
Stage 2: Moderate (2-10 years)
Difficulty making decision as a result of decreased concentration
Stage 2: Moderate (2-10 years)
Lack the cognitive skills to make appropriate judgments
Stage 2: Moderate (2-10 years)
Develop delusion that are paranoid in nature
Stage 2: Moderate (2-10 years)
Both short- and long-term memory are affected
Stage 2: Moderate (2-10 years)
Perseveration
Stage 2: Moderate (2-10 years)
Sundowning
Stage 2: Moderate (2-10 years)