Tetracyclines

Question 1

Rickettsia (Rocky mountain spotted fever)

Answer 1

Doxycycline

Question 2

Borrelia Bergdorferi (tick born lyme disease)

Answer 2

Doxycycline

Question 3

Chlamydia trachomatis

Answer 3

Doxycycline

Question 4

cidal or static

Answer 4

static

Question 5

mechanism of resistance

Answer 5

• tetracycline efflux pump

- methylation of ribosome

Question 6

What is the name of the efflux pump that conveys resistance

Answer 6

Tet A

Question 7

What is the only tetracycline that is safe to use in renal impairment

Answer 7

Doxycycline

Question 8

Adverse effects of tetracyclines

Answer 8

• GI superinfection
• Accumulation in teeth and bone
• Fatal hepatotoxicity (fatty liver during pregnancy)
• Phototoxicity
• Vestibular probems
• Diabetes insipidus

Question 9

What should you not take with tetracyclines because it disrupts absorption

Answer 9

• antacids

- dairy food

Question 10

What age are tetracyclines contraindicated for?

Answer 10

under 8 due to accumulation in teeth and bones

Question 11

3 people that tetracyclines are contraindicated for?

Answer 11

• pregnant
• breast feeding
• children under 8

Question 12

What is the super infection that can develop in the GI tract when taking tetracyclines

Answer 12

-C. diff causing a potentially life threatening pseudomembranous colitis

Question 13

What is the improved relative of tetracyclines that is save for patients with renal impairment, has decreased susceptibility by Tat A efflux pumps, and has a greater spectrum of activity

Answer 13

Tigecycline

Question 14

MOA for tetracyclines

Answer 14

Block binding of aminoacyl-tRNA

Question 15

metabolism

Answer 15

enterohepatic recirculation

Question 16

What organ do tetracyclines concentrate in?

Answer 16

liver