Thiazide Diuretics Flashcards

(4 cards)

1
Q

What are the examples of hydrochlorthiazide (prototype)?

A
  • chlorthalidone
  • indapamide
  • metolazone

These are thiazide-like diuretics that share similar mechanisms of action.

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2
Q

What are the contraindications for hydrochlorthiazide?

A
  • Renal failure (oliguria, ↑BUN, ↑Cr)
  • Pregnancy and breastfeeding

These conditions may lead to adverse effects or complications when using the medication.

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3
Q

What is the action of hydrochlorthiazide?

A
  • Act on distal convoluted renal tubule
  • Promote sodium, chloride, and water excretion
  • Promote Ca++ reabsorption so ↓risk for post menopausal osteoporosis

This mechanism helps in managing blood pressure and preventing osteoporosis.

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4
Q

What are the uses of hydrochlorthiazide?

A
  • Hypertension
  • Peripheral edema

It is commonly prescribed to manage high blood pressure and fluid retention.

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