Three fires
They are greed, hatred, and ignorance.
They are called fires as they keep the flame of existence burning until they are extinguished.
They are called poisons as they corrupt humans, underpinning bondage, and misery.
Negative karma
Negative karma you gain from the three poisons are significant as it can lead to you being born in a lower realm.
Dukkha
They cause dukkha as it is as a result of our attachment that we suffer.
Not only poisons
Bhavachakra
It is important by how it is depicted at the centre of the Bhavachakra.
Peter Harvey
Argues that the three fires lead to morally wrong acts as he links wrong view with wrong thought and eventually wrong act.