Thrombolytics

Question 1

What is the MOA of Thombolytics?

Answer 1

Basically to just turn Plasminogen to Plasmin, which will affect the cross-linked fibrin. Causing the clot to dissolve.
-can increase bleeding risk

Question 2

What are the two things need to activate plasminogen to plasmin?

Answer 2

XIIa and t-PA
-t-PA is inhibited my PAI-1 and PAI-2

Question 3

What is Alteplase?

Answer 3

Thrombolytic Drug used for Acute MI, Stroke, and PE.
-Short t1/2
-cleared in the liver & kidney

Question 4

What is streptokinase?

Answer 4

a catalyst that converts plasminogen to plasmin BUT it doesn’t direct dissolve clots.