1
Q
Hemostasis conclusion
A
When blood vessel defect has healed, fibrinolytic pathway is activated to dissolve the clot
2
Q
Thrombolytic drugs MOA
A
Increase conversion plasminogen -> plasmin
Plasmin degrades fibrin and dissolves clot
3
Q
Indications for thrombolytic therapy
A
Acute MI
Acute ischemic thrombotic stroke
PE
4
Q
Tissue plasminogen activators (t-PA)
A
Alteplase
Reteplase (faster onset)
Tenecteplase (longer duration of action)
5
Q
Anti-fibrinolytic agents
A
Used to stop bleeding from thrombolytic drugs
Tranexamic acid
Aminocaproic acid (EACA)
Lysine
PHRM844
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