Thyroid

Question 1

Mechanism of cell destruction in thyroid

Answer 1

Cytotoxic cd8+ cell death
Thyroglobulin and TPO antibodies secondary damage but no effect alone
Rarely antibodies against tsh receptor block effect of tsh

Question 2

Risk factors for graves

Answer 2

1. female
2. Genetics HLAB8 HLA DR3,DR2
3. E.coli and other gram negative- by molecularly mimicry
4. Smoking
5. Stress
6. High iodine intake