Benign
Adenoma
- encapsulated in collagen
Malignant
Papillary
Follicular
Medullary
Anaplastic
Papillary
Most common Young adults Lymphatic spread Usually solitary (Adeno) Orphan Annie nuclei Psommama bodies Mutations in RAS & BRAF Good survival - lobectomy
Orhan Annie nuclei
Papillary thyroid cancer
Psommam bodies
Papillary thyroid cancer
Follicular
2nd most common Older (40-50) Haematogenous spread Iodine deficiency, P13K AKT Invasive
Medullary
From c-cells that secrete calcitonin
Total thyroidectomy
Associated with MEN2
Anaplastic
Undifferentiated & aggressive
Involves neck structures causing death
Chemo & radio
Most common
Papillary
Most dangerous
Anaplastic