Thyroiditis

Question 1

define

Answer 1

this is inflammation of the thyroid

Question 2

causes

Answer 2

Hashimoto's thyroiditis
Grave's
infection
palpation
subacute lymphocytic (viral)
post-partum
active suppurative thyroiditis (bacterial)
drugs (amiodarone, lithium)
de Quervain's
Riedel's

Question 3

what is AI thyroiditis associated with?

Answer 3

polymorphisms in immune regulation- CTLA-4 and PTPn-22

Question 4

what patient group is sub-acute thyroiditis commonly seen in?

Answer 4

females

20-50

Question 5

what can trigger sub-acute thyroiditis?

Answer 5

viral infection

Question 6

presentation of sub-acute thyroiditis

Answer 6

neck tenderness
fever
other viral symptoms
usually self-limiting

Question 7

what impact does amiodarone have on the thyroid?

Answer 7

TFTs are abnormal in 50% as inhibition of DIO1 increases T4 and lowers T3 with normal TSH

risks hypothyroidism (iodine rich) and hyperthyroidism (iodine deficient)