Thyrotoxicosis

Question 1

Thyrotoxicosis: clinical disorder resulting from ? circulating levels of thyroid
hormone.
Effects ?% of the population.
Far more common in ? (5:1).

Answer 1

raised
1
women

Question 2

Causes;
Common;

o ? disease.
• lgG ? stimulate thyroid follicular cells, out of control of the normal ? feedback mechanism.
• It has certain specific signs on examination (see below) .

o ? ? goitre.
• Commonly in ? ?, where several ? nodules develop, outside of ? control.

Answer 2

grave's
autoantibodies
pituitary
toxic multinodular
old women
hyperactive
TSH

Question 3

Causes
Less common;
o ? toxic ?.
---• Aka ? 's disease, as above but just one nodule.
o Thyroiditis.
o ?-induced.
---• ?, excess ?.
o Excess ? intake.
o Hashitoxicosis.
• ? ? of Hashimoto's .

Rare;
o Secondary causes .
–• ? secreting ? adenoma .
–• ? to thyroid hormone .

Answer 3

solitary adenoma
plummers
drug
amiodarone
levothyroxine
iodine
hyperthyroid phase
tsh
pituitary
resistance

Question 4

Symptoms;
? / irritability.
? intolerance/ ?.
? appetite.
? (heart).
? loss.
Tremor.
Stool is ?
Fatigue / ?.

Answer 4

anxiety
heat
sweating
increased
palpitations
weight
loose
weakness

Question 5

Signs;
Lid ? / lid ?.
Graves' ?
Goitre / ?
? hypertension.
Tachycardia/ ? .
Tremor.
Hyper-?.
? peripheries.
?
? weakness .
Pre-? ?

which of these are Grave’s specific

Answer 5

lag
retraction
ophthalmopathy !!
bruit !!
systolic
AF
reflexia
warm
acropachy !!
proximal
tibial myxoedema !!

Question 6

Graves opthalmopathy is much more common in ?

Answer 6

smokers

Question 7

A rare presentation is thyroid crisis / thyroid ‘storm

Generally occurs in periods of ? (infection, surgery, ?) in people with ?/? hyperthyroidism;
o Hyper?
o Severe ?.
o Profuse ?.
o Confusion / ?
.
If untreated, ? and ? may ensue.
o Treat with ?, ?, sodium ?, high dose
? and supportive measures.

Answer 7

stress
childbirth
uncontrolled/untreated
pyrexia
tachycardia
sweating
psychosis
coma
death
propylthiouracil
propranolol
iodide
steroids