- **14th Jan** Treaty of Madrid between France and Spain, Francis renounces his claims in Italy and concedes Burgundy to Charles
- **10th Mar** Charles marries Isabella of Portugal, who was to act as regent in his absence, which was popular in Spain
- Council of State established
- Erasmus’ ‘handbook for a Christian soldier’ translated in Castilian and published
- Charles visits Granada on honeymoon and informed of Moriscos impiety, he is paid of from intervening by farda tax
- **June** Pope Clement VII formed alliance (Cognac league) against Charles, aiming to reclaim Italian territories