If Ka decreases…
- like a change in dosage form
- Peak height decreases
- Peak time increases
- AUC/half-life stays the same
If F decreases…
- like an increase in gastric decomposition
- Peak height decreases
- AUC decreases
- Peak time/half-life stays the same
If V decreases (or k increases)…
- like a decrease in tissue binding
- Peak height increases
- Peak time/half-life decreases
- AUC stays the same
If CL decreases (or k decreases)…
- like renal or hepatic disease
- Peak height, peak time, AUC, half-life all increase
Sink conditions are maintained
C is kept very low
Particle size is reduced
Area (A) is increased for a given amount of drug
Salt form is used, instead of acidic form
Solubility (Cs) is increased
The solution is stirred at a higher speed
The thickness of the stagnant layer (h) is decreased
The volume of the container is increased
C is lower at each point in time as the drug dissolves
A less soluble salt of a basic drug is used instead of the hydrochloride salt
Solubility (Cs) is decreased
Inactive ingredients are added which hasten the disintegration/ deaggregation of tablets.
Area (A) is increased more quickly with time
