Topic 6

Question 1

Changes in the dissociation reaction can affect

Answer 1

pH of solution

Question 2

Temperature affects

Answer 2

dissociation of molecules in solution

Question 3

decreased temperature produces

Answer 3

• decrease in energy which produces
• decrease in dissociation which produces
• decrease in concentration of all IONIZED components
• Equilibrium of dissociation moves to the LEFT

Question 4

At equilibrium, the pH produced is called the

Answer 4

pH of neutrality

At 27C, the pH of neutrality is 7.0

Question 5

Henry’s law formula

Answer 5

Dissolved = Solubility x Partial Pressure

Question 6

Solubility

CO2 @ 37 degrees C =

Answer 6

0.06 mls CO2/100 mls bld/mmHg

Question 7

Solubility

O2 @ 37 degrees C =

Answer 7

0.003 mls O2/100 mls bld/mmHg

Question 8

How is CO2 moved from tissue to lungs

Answer 8

Dissolved
Bound to hemoglobin
As HCO3-

Question 9

Haldane Effect

Answer 9

Represents affect of PO2 on ability of CO2 to bind to hemoglobin

Question 10

Content ≈

Answer 10

Solubility x PP

Question 11

PP ≈

Answer 11

Content / Solubility

Question 12

Solubility is inversely proportional to

Answer 12

temperature

Question 13

Temperature increases, then Solubility

Answer 13

decreases

Question 14

Temperature decreases, then Solubility

Answer 14

increases

Question 15

change the pH of blood in a “closed” system via option A=

Answer 15

Change CO2 content and keep temp constant

Question 16

change the pH of blood in a “closed” system via option B=

Answer 16

Change temp and keep total CO2 content constant

Question 17

change the pH of blood in a “closed” system via option C=

Answer 17

Change CO2 content and change temp

Question 18

Option A: Increase total CO2 content by ADDING additional CO2 will cause

Answer 18

pCO2 will increase

pH will decrease

Question 19

Option A: Decrease total CO2 content by REMOVING CO2 will cause

Answer 19

pCO2 will decrease

pH will increase

Question 20

Option A: No change in temperature means

Answer 20

No change in solubility

No change in acid-base disassociation equilibriums

Question 21

Option B: Increase temperature will cause

Answer 21

Drive acid-base disassociation equilibrium to the right
[H+] will increase
pH will decrease

Question 22

Option B: Decrease temperature will cause

Answer 22

Drive acid-base disassociation equilibrium to the left
[H+] will decrease
pH will increase

Question 23

Option B: No change in total CO2 content means

Answer 23

pCO2 WILL change due to change in solubility, BUT NO CORRESPONDING change in pH

Question 24

Option C: Change total CO2 content will cause

Answer 24

pCO2 will change producing an inverse change in pH

Question 25

Option C: Change temperature will cause

Answer 25

Disassociation equilibrium will change causing a corresponding increase or decrease in [H+]

Question 26

Option C Result will be a

Answer 26

bigger/smaller change in pH than might be expected

Question 27

Blood in a closed system (no change in CO2 content)… | Temperature Increases ... then Gas solubility

Answer 27

decrease

Question 28

Blood in a closed system (no change in CO2 content)… | Temperature Increases ... then Gas partial pressure

Answer 28

increase

Question 29

Blood in a closed system (no change in CO2 content)… | Temperature Increases ... then gas pressure is _____ than the starting gas pressure

Answer 29

higher

Question 30

Blood in a closed system (no change in CO2 content)… | Temperature Increases ... then Equilibrium of the water dissociation shifts to the

Answer 30

right

Question 31

Blood in a closed system (no change in CO2 content)… | Temperature Increases ... then pH will

Answer 31

decrease

Question 32

Blood in a closed system (No change in CO2 content)… | Temperature Decreases... then Gas solubility

Answer 32

increases

Question 33

Blood in a closed system (No change in CO2 content)… | Temperature Decreases... then Gas partial pressure

Answer 33

decreases

Question 34

Blood in a closed system (No change in CO2 content)… | Temperature Decreases... then gas pressure is ____ than the starting gas pressure

Answer 34

lower

Question 35

Blood in a closed system (No change in CO2 content)… | Temperature Decreases... then Equilibrium of the water dissociation shifts to the

Answer 35

left

Question 36

Blood in a closed system (No change in CO2 content)… | Temperature Decreases... then pH will

Answer 36

increase

Question 37

Blood Gas Determination Via Lab=

Answer 37

1. Draw sample (Remove all air from sample – Cap tightly – Place in cup of ice) 2. Blood from sample injected into analyzer 3. Analyzer WARMS sample to 37C 4. Analyzer determines the pO2, pCO2, and pH at 37C

Question 38

Blood gas analyzers heat the blood to 37C before measuring parameters- effects pO2 and pCO2 how

Answer 38

Decreases solubility of gases in sample so PO2 and PCO2 will be artificially high at 37C

Question 39

Blood gas analyzers heat the blood to 37C before measuring parameters- effects pH how

Answer 39

Pushed HOH equation to right so pH will be artificially low at 37C

Question 40

Uncorrected gases=

Answer 40

Report gas values determined at 37C

Question 41

Corrected gases=

Answer 41

Report gas values measured at 37C then corrected back to actual body temperature

Question 42

Temperature Correction of Blood Gases | -Patient temp is 25 so analyzer will WARM the sample- which means that...

Answer 42

pH will be lower than expected (0.0147 per degree) CO2 will be higher than expected O2 will be higher than expected