Toxicities

Question 1

Agents that DO NOT cause myelosuppression (3)

Answer 1

Asparginase
Bleomycin
Vincristine

Question 2

Neuropathy (4)

Answer 2

Platinum Agents (cisplatin, etc)
Protease Inhibitors
Taxanes
Vinca Alkaloids

Question 3

Cardiotoxicity

Answer 3

ANTHRACYCLINES
Breast Cancer drugs (trastuzumab, lapatinib)
CML TKIs (imatinib, nilotinib, dasatinib)

Question 4

Pulmonary Toxicity (4)

Answer 4

Bleomycin
Methotrexate
Busulfan
Carmustine/Lomustine

Question 5

Nephrotoxicity/Cystitis (Bladder Toxicity) (5)

Answer 5

Ifosfamide > Cyclophosphamide
*Mesna*
Arsenic
Bevacizumab
MTX
Platinum Agents 
(cisplatin *Amifostene*)

Question 6

Acneiform Rash

Answer 6

EGFR Inhibitors

cetuximab, erlotinib, panitumumab, sorafenib, sunitinib

Question 7

Mucositis (3)

Answer 7

5-FU / capecitabine
Irinotecan
MTX

Question 8

Hand-foot Syndrome (5)

Answer 8

Capecitabine (Xeloda®)
Fluorouracil (5-FU®)
Doxorubicin (Adriamycin®)
Liposomal doxorubicin (Doxil®)
Cytarabine (Cytosar-U®)

Question 9

Hand-foot Skin Reaction (9)

Answer 9

Sorafenib (Nexavar®)
Sunitinib (Sutent®)
Cabozantinib (Cometriq®)
Regorafenib (Stivarga®)
Axitinib (Inlyta®)
Pazopanib (Votrient®)
Vandetanib (Caprelsa®)
Vemurafenib (Zelboraf®)
Dabrafenib (Tafinlar®)

Question 10

Alopecia (6)

Answer 10

TAXANES (paclitaxel, docetaxel)
ANTHRACYCLINES (doxorubicin, etc)
Ifosfamide / Cyclophosphamide
Carboplatin
Etoposide
Vinca Alkaloids (vincristine, etc)

Question 11

Extravasation (Vesicants) (6)

Answer 11

Anthracyclines *DMSO or dexrazoxane
Vinca Alkaloids *Hyaluronidase + HEAT
Ixabepilone
Mitomycin
Etoposide *HEAT
Mechlorerhamine *sodium thiosulfate

Question 12

Hepatotoxicity (7)

Answer 12

Folate + Pyrimidine Analogs (MTX)
Taxanes
Vinca Alkaloids
Busulfan
Aromatase Inhibitors / SERMS
Ixabepilone
some TKIs