Toxicity

Question 1

Question 2

Describe therapeutic dose.

Answer 2

-minimal therapeutic dose: smallest dose to get therapeutic effect
-maximal therapeutic dose: largest dose to get therapeutic effect w/o toxic effects
wider the therapeutic window = safer the drug

Question 3

Describe toxic VS lethal dose.

Answer 3

1. Toxic
   -dose that causes undesirable effects
2. Lethal
   -dose that causes death

Question 4

Describe effective dose 50 & toxic dose 50.

Answer 4

1. ED50
   -dose that’s therapeutic to 50% of treated patients
   -ED99 -> therapeutic in 99% of treated patients
2. TD50
   -dose that causes side effects to 50% of treated patients
   -TD1 -> side effect in 1% of treated patients
   same for lethal dose LD

Question 5

Describe therapeutic index.

Answer 5

-ratio between toxic dose 50 & effective dose 50 or lethal dose & effective dose in humans
-safer drugs = higher therapeutic index

Question 6

Describe standard safety margin & certain safety factor.

Answer 6

safer than the therapeutic index = higher they are = safer the drug
1. SSI
-percentage dose inc between ED99 & LD1
2. CSF
-ratio between ED99 & LD1

Administration a dose X time higher than the ED99 will be administrating LD1