Related to spoiled dark meat fish
Histamine toxin due to scombroid poisoning
Bacerial histidine decarboxylase converts histidine to histamine
mimics anaphylaxis
Pufferfish
Tetrodotoxin
binds fast voltage Na channels in cardiac and nerve tissues preventing depolarization
AR: paresthesias, weakness, loss of reflexes
Reef fish
Ciguatoxin
opens Na channels causing depolarization
AR: perioral numbness, reversal of hot and cold sensations, heart block