ToxPath

Question 1

Which transporter is only expressed in the liver

Answer 1

Bsep

Question 2

Aromatic armines MOA

Answer 2

glucuronidation and sulfonation increase carcinogenic potential (of parent agents and their hydroxylamine metabolites)

Question 3

Bilirubin MOA tox

Answer 3

competition by drugs for UGT1A1 yields hyperbilirubinemia

Question 4

NSAID MOA tox

Answer 4

reactive acyl-glucuronides damage macromolecules

Question 5

Favored phase II method of detox?

Answer 5

Glucuronidation is favored in most species but is low-capacity pathway in cats (use sulfonation instead)

Question 6

Which are the major routes of excretion of toxic. metabolites?

Answer 6

Urinary and biliary

Question 7

What plays a critical role in biliary excretion

Answer 7

Xenobiotic transporters in the liver