Translocations

Question 1

t(15;17)

Answer 1

APML

Question 2

t(9;22)

Answer 2

CML
Philadelphia chromosome
BCR-ABL

Question 3

t(8;14)

Answer 3

Burkitt’s lymphoma
C-myc activation

Also t(2;8) and t(8;22)

Question 4

t(14;18)

Answer 4

Follicular

BCL2

Question 5

t(2;5)

Answer 5

Anaplastic large cell lymphoma, ALK+

Question 6

t(11;14)

Answer 6

Mantel cell

Cyclin D1 overexpression

Question 7

t(11;18) in gastric extra-nodal MZL

Answer 7

Predicts lack of response to H.pylori eradication

Question 8

Myeloma high risk cytogenetics

Answer 8

t(4;14)
t(14;16)
t(14;20)
del 17p
gain 1q