Translocations

Question 1

t (8:14)

Answer 1

• Burkitts Lymphoma
• C-myc gene

Question 2

t (9:22)

Answer 2

• CML
• BCR-ABL tyrosine kinase gene mutation

Question 3

t (11:14)

Answer 3

• Mantle cell Lymphoma
• Cyclin D1 gene

Question 4

t (14:18)

Answer 4

• Follicular Lymphoma
• BCL-2 gene mutation

Question 5

t (15:17)

Answer 5

• APL (M3 type AML)
• Responds to All trans retinoic acid (Vit-A)

Question 6

t (11:22)

Answer 6

Ewings Sarcoma

Translocation of protien EWS FLI-1

Onion skin bone appearence on X-ray