1
Q
t(9;22)
A
Philadelphia chromosome CML Some ALL (adults, poor prognosis)
Tx = imatinib
2
Q
t(8;14)
A
Burkitt lymphoma
c-myc activation
Associated with EBV
3
Q
t(11;14)
A
Mantle cell lymphoma
Cyclin D1 activation (promotes G1 –> S)
4
Q
t(14;18)
A
Follicular lymphoma
Bcl-2 activation (stabilizes mitochondrial membrane so apoptosis cannot occur)
5
Q
t(15;17)
A
M3 type of AML
Acute promyelocytic Leukemia
Tx = all-trans retinoic acid (induces maturation of blasts)
6
Q
t(12;21)
A
B-ALL
Children
Good prognosis
USMLE
flashcards
Decks in class (38)
# Cards
-
Classic Presentations118
-
Classic Labs/Findings105
-
Classic/Relevant Treatments91
-
Key Associations130
-
Equations31
-
Antidotes21
-
Antibiotics to Avoid in Pregnancy9
-
Food Poisoning7
-
Normal Dominant Flora7
-
Bloody Diarrhea8
-
Watery Diarrhea7
-
Teratogens13
-
Electrolyte Disturbances33
-
Renal Pathology5
-
Rate Limiting Enzymes26
-
Neoplasia Pathology38
-
Oncogenes11
-
Tumor Suppressor Genes16
-
Tumor Markers12
-
Oncogenic Microbes and Carcinogens20
-
Parasite Associations8
-
Bug Hints19
-
Lymph Drainage14
-
HLA Subtype Associations7
-
Autoantibodies44
-
Hypersensitivity Disorders30
-
Translocations6
-
Cardiac Maneuvers35
-
Heart Murmurs17
-
Congenital Cardiac Defect Associations6
-
Casts in Urine16
-
Kidney Stones25
-
Serum Markers Liver/Pancreas Pathology6
-
Neurotransmitters20
-
Hypothalamus8
-
Drug Intoxication Withdrawal50
-
Hereditary Cancer Syndromes17
-
Microbiology31
