Tuberculosis

Question 1

TB treatment

Answer 1

initial phase: RIPE
rifampicin
isoniazid
pyrazinamide
ethambutol

pyridoxine (vit B6) may be prescribed alongside for peripheral neuropathy

2 MONTHS

continuation phase:
rifampicin
isoniazid

4 MONTHS

Latent TB - 3 months of rifampicin + isoniazid or 6 months of isoniazid
- pts with latent TB aged 35-65 should be cleared of hepatotoxicity

Question 2

rifampicin imp points

Answer 2

discolours soft contact lenses and bodily fluids orangey-red
- can’t have contact lenses

cyp450 inducer

Question 3

isoniazid

Answer 3

peripheral neuropathy - give prophylactic pyridoxine (vit B6)

CYP450 inhibitor

Question 4

pyrazinamide and ethambutol imp points

Answer 4

pyrazinamide - hepatotoxic

ethambutol - visual impairment + ocular toxicity