TZD

Question 1

Thiazolidinediones examples

Answer 1

(TZDs)

“glitazones”

Question 2

TZD MOA

Answer 2

PPARγ agonist (nuclear receptor) –> gene transcription to inc insulin sensitivity

Question 3

TZD effects on fat

Answer 3

Inc AMPK & insulin sensitivity @ target tissues

Question 4

TZD effects on fat - cytokines

Answer 4

INC:
“good” adipocytokines
inflam cytokines

DEC:
“bad” cytokines

Question 5

TZD effects on SKM

Answer 5

Inc GLUT4 translocation –> inc glucose uptake

Question 6

TZD effects on Liver

Answer 6

Dec hep glucose produx

Question 7

TZD - which may have PPAR alpha agonist activity?

Answer 7

Pioglitazone

Question 8

TZD AE

Answer 8

Hepatotox
Edema
Weight gain 
Osteoporosis
Bladder cancer risk (pioglitazone)

Question 9

TZD considerations - onset

Answer 9

Relatively slow effects (1-2 weeks onset; 2-3 months

max effect: due to genomic effects?)

Question 10

Baseline & monitor ____

Answer 10

AST
ALT
Edema

Question 11

Monitor for signs of ____

Answer 11

HF

Question 12

TZD CI

Answer 12

Symptomatic HF
Bladder cancer  (hist or act)
Bone fracture (hist or risk)
Liver dz (active)