ulcerative colitis

Question 1

where does ulcerative colitis affect?

Answer 1

• colon only
• starts at rectum- sigmoid- proximal colon

Question 2

does ulcerative colitis go through wall?

Answer 2

no
remains in mucosa
- doesn’t go through wall

Question 3

does ulcerative colitis have skip lesions?

Answer 3

NO
- its continuous

Question 4

does UC have granulomatous tissue?

Answer 4

NO

Question 5

what are the goblet cells like in UC?

Answer 5

depleted

Question 6

describe the crypt abscesses in UC

Answer 6

increased

Question 7

how is UC diagnosed?

Answer 7

1. pANCA positive
2. colonoscopy
3. biopsy

Question 8

what would a UC colonoscopy show?

Answer 8

• continuous leadpipe sign

Question 9

what would a biopsy for UC show?

Answer 9

• mucosal inflammation with crypt hyperplasia

Question 10

how do you determine the severity of flare?

Answer 10

• truelove and witts scoring
• mild/mod/severe

Question 11

what are the symptoms for UC?

Answer 11

• LLQ pain
• Tenesmus - rectal infection pain
• Diarrhoea with blood, water and mucus
• extra intestinal symptoms

Question 12

what are the extra intestinal symptoms for UC?

Answer 12

• Uveitis/ episcleritis
• erythema nodosum
• spondylarthropathy
• PSC- Primary sclerosis cholangitis

Question 13

what are the complications of UC?

Answer 13

• toxic megacolon

Question 14

what are the risk factors of UC?

Answer 14

NSAIDS
stress
jewish
smoking protects!!!!

Question 15

how is UC treated for flares?

Answer 15

sulfasazine + prednisolone

Question 16

how is UC treated for remission?

Answer 16

azathioprine, methotrexate, lidosporin

Question 17

how is UC treated with biologics?

Answer 17

anti TNF alpha - infliximab

Question 18

what are the 4 ways UC is treated ?

Answer 18

1. flares
2. remission
3. biologics
4. surgery- CURATIVE