1
Q
how may antigens does diego have
A
22
2
Q
diego has three sets of high and low pairs of antithetical antigens—
A
Dia/Dib, Wra/Wrb, and Wu/DISK
3
Q
No racial difference and null phenotype
A
diego
4
Q
expressed on BAND3 or red blood cell anion exchanger protein 1 (AE1}
A
DIEGO
5
Q
are expressed on RBCs of newborns and in kidney of adults (collecting ducts)
A
Diego antigen
6
Q
A
7
Q
A
8
Q
The gene encoding band 3 and the Diego antigens,
A
SLC4A1
9
Q
Role in acid secretion in HCO3 reabsorption
A
Anion exchanger (AE1)
10
Q
Chloride shift/ hamburger shift (which is located extracellularly). Bale chloride is dispersed in exchange for bicarbonate
A
AE1
11
Q
AE1 defect:
A
congenital acanthocytosis, hereditary spherocytosis and southeast asian ovalocytosis
12
Q
INC in HCO3 capacity and osmotic resistance
A
Mittenberger II red cells
13
Q
Higher AE1 expression
A
Mittenberger II red cells
14
Q
contributed to red cell senescence - affected by cold storage which increases it
A
AE1
15
Q
is rare in most populations but is polymorphic in people of Mongoloid ancestry
A
Dia
16
Q
The is located on the last (seventh) extracellular loop of the protein.
A
Dia/Dib polymorphism
17
Q
associated with an amino acid substitution on the fourth external loop, close to the insertion point of the protein into the RBC membrane.
A
Wra and Wrb
18
Q
expression of requires the interaction of band 3 and normal GPA of the MNS blood group system.
A
Wrb
19
Q
GPA-deficient RBCs are
A
Wr(a–b–).
20
Q
is a relatively common antibody in donors and patients; some are directly agglutinating, but most require the antiglobulin phase of testing to be detected.
A
Anti-Wra
21
Q
which antigens of diego causes htr and hdfn
A
dia = HDFN
Wra = severe HTR
elo = severe hdfn
22
Q
in diego, is relatively common in the serum of patients with warm autoimmune hemolytic anemia.
A
Autoanti-Wrb
23
Q
antithetical and represent an amino acid substitution on the glycosylphosphatidylinositol (GPI) linked RBC glycoprotein acetylcholinesterase (AChE).
A
cartwright
24
Q
does cartwright have a null phenotype
A
no
25
expressed on RBCs, neural synapses, neuromuscular junctions
cartwright
26
expressed weaker on cord RBCs than on adult RBCs
cartwright
27
wala CD59/MIRL and CD55 (Accelerated factor) both are important in the removal of activated complement system
pnh
28
is an important enzyme participating in neurotransmission, but the function of RBC-bound AChE is not known
AChE
29
ache what chromosome
chromosome 7
30
stimulated by pregnancy and transfusion
Anti-Yta and Ytb
31
also more likely to cause a positive monocytemonolayer assay with decreased red cell survival
yta antigen
32
was discovered in 1962 in the serum of a multiply transfused man.
Anti-Xga
33
higher prevalence in females than in males
xg
34
The gene responsible for CD99, ,
MIC2
35
became part of the Xg system because the _____and XG genes are adjacent and homologous
cd99
36
Japanese individuals were found with
anti-CD99.
37
Xga has a phenotypic relationship to :
CD99
38
all Xg(a+) individuals have a ___expression of CD99 on their RBCs,
high
39
sc antigens
Antigens
SC1 – Sm
SC2 – Bua
SC3
SC4 – Radin
SC5 – STAR
SC6 – SCER
SC7 – SCAN
40
high incidence scianna
sc1,3,5,6,7
41
Specific for RBC and Erythropoietic Tissues
scianna
42
expressed on cord RBCs and ERMAP
scianna
43
Can cause autoimmune hemolytic anemia
scianna
44
scianna antibody associated with hdfn
anti-Sc4 and Anti-sc2
45
scianna associated with waiha
sc1 and sc3
46
phenotype is the Scianna null type.
Sc:–1,–2,–3
47
The low-prevalence sc antigen
Rd became Sc4.
48
ERMAP what chromosome
1
49
RBC adhesion protein involved in cell signalling
ermap
50
could be involved in immune recognition and autoimmune anemia
ermap
51
dombrock antigens
Antigen: Gya, Hym, DOYA and DOMR
52
carried on a mono-ADP ribosyltransferase 4 (ART4) attached to the RBC membrane by a GPI anchor. Carried by chromosome 12
Dombrock
53
Dombrock mRNA has been identified In: RBC,
fetal liver and spleen
54
is Delayed HTR only. not associated with HDFN
Anti Dombrock
55
commonly found in mixtures of alloantibodies and can be difficult to identify
dombrock
56
High prevalence antigen of dombrock
: Gya, Hy, Joa
57
clearing circulating NAD+ and/of posttranslational modification of proteins
dombrock
58
may also contribute to integrin-mediated cell adhesion
Dombrock
59
colton antigens
consists of four antigen: Coa, Cob, Co3,Co4
60
The antigens are expressed on RBCs of newborns
Colton
61
The Colton antigens are carried on an integral membrane protein, aquaporin 1 (AQP1), which accounts for 80% of water reabsorption in the kidneys.
The Colton (015) System
62
a high-prevalence antigen, has been identified on RBCs from two individuals with the Co(a–b–) phenotype.
Co4
63
is present on all RBCs except those of the very rare Co(a–b–) phenotype
Co3
64
65
reacts with all Co(a+) and Co(b+) RBCs, has been reported to cause mild HTR and severe HDFN.
co3
66
landsteiner weiner
There are three LW antigens: LWa, Lwab, and LWb
67
Expression of _____antigen is dependent on RhD protein expression
LW
68
Plasma origin, adsorbed from rbc
lw, ch/rg
69
Can rarelycause htr and hdfn
lw
70
Carries by intracellular adhesion molecule 4 (ICAM-4), a member of the immunoglobulin superfamily.
lw
71
72
antigens may be depressed during pregnancy and in some diseases, such as lymphoma and leukemia.
LW
73
common in serum from patients with warm autoimmune hemolytic anemia. in lw
Autoanti LW
74
a potential counterreceptor for the 2 integrin protein Macl (CD11b/CD18), LFA 1 (CDIla/CD18), and platelet GPIlb /illa
LW glycoprotein
75
may participate in adhesive interactions during early erythroid development
LW glycoprotein
76
expression is elevated in sickle cell patients and may be involved in microvascular occlusion
LW
77
is of low prevalence, found in less than 1% of most Europeans but in 6% of Finns.
LWb
78
was originally defined by the antibody made by an individual with an inherited LW(a–b–) phenotype
LWab
79
Distinguishing anti-LW from anti-D is most easily accomplished by testing
DTT-treated D+ RBCs:
80
Serologically, they were both characterized as nebulous because antigen strength on different samples of RBCs was variable.
CHIDO ROGERS
81
weakly expressed on cord RBCs and some GYPA deficient RBCs
chido rogers
82
Rare reports of anaphylaxis plasma and platelet transfusion
chido rogers
83
they are on the fourth component of complement (C4)
chido and rogers
84
Deficiency is associated with autoimmune disorders including autoimmune disorders and susceptibility to bacterial meningitis
C4 glycoprotein
85
rheumatoid arthritis and graves disease
c4 C4 glycoprotein
86
gerbich antigens
six high-prevalence Gerbich antigens
Ge2, Ge3, Ge4, GEPL, GEAT, and GETI) and
five low-prevalence antigens
Wb, Lsa, Ana, Dha, and GEI
87
The antigens are carried on sialoglycoprotein structures GPC and GPD.
gerbich
88
Decreased antigens in patients with hereditary elliptocytosis due to protein deficiency
gerbuch
89
most common of the Gerbich antibodies.
Anti-Ge2
90
Autoantibodies cause severe autoimmune hemolytic anemia
gerbich
91
Gerbich null phenotype.
Ge null (Leach) type
Ge:–2,–3,–4
92
associated with marked elliptocytosis due to reduced membrane stability and deformability
Ge null (Leach) type
93
are elliptocytic and these individuals may have a mild anemia.
The RBCs of Ge null phenotype
94
has been found in Mexicans, Israelis, Mediterraneans, and others but has not been found in Papua, New Guinea.2,3
Yus phenotype
95
is polymorphic in certain areas of Papua, New Guinea, and has also been found among Europeans, Africans, Native 217 Americans, Japanese, and Polynesians.
Gerbich phenotype
96
similar to Diego/Band 3, help anchor the membrane to the underlying cytoskeleton
GYPC and GYPD
97
rich in sialic acid can bind influenza virus
GYPC and GYPD
98
binds p. Falciparum strains owing its part to its n glycan
GYPC
99
is the ancestral protein and is shared among all primates
GYPD
100
: Formation of an upstream codon with synthesis of GYPC is new and limited to humans
GYPD
101
The Cromer system has antigens listed on the current ISBT website.
20
102
carried on decay accelerating factor (DAF, CD55), a complement-regulatory protein.
The Cromer (021) System N
103
inhibited by plasma, urine, and platelet concentrates
Cromer
104
in several cases, a transient loss of anti ___was noted in the second and third trimesters with reappearance of the antibody following delivery
cromer antibodies
105
inhibited by plasma, urine, and platelet concentrates
cfomer
106
destroyed by α-chymotrypsin,
cromer
107
protects cells from complement by promoting the decay of two C3 convertases: C4b2a and СЗЬВЬ
cromer
108
receptor for:
uropathogenic and intestinal E. coli strains bearing Afa /Dr and X adhesins
echovirus
coxsackie B virus
CD55/DAF
109
appears to be a novel Inab-like phenotype with a mutation that affects the expression of the Cromer antigens.
CROK (CROM19)
110
characterized by complete absence of all Cromer antigens but normal expression of CD59 and other GPI linked glycoproteins
INAB PHENOTYPE
111
many individuals with the Inab phenotype suffer from chronic gastrointestinal disorders , particularly a chronic protein losing gastroenteropathy
INAB PHENOTYPE
112
autoimmune anemia due to autoanti AnWj has been reported
The Indian (023) System
113
Carried on CD147, or basigin
Ok
114
on WBCs, is a leukocyte activation associated protein may participate in cell adhesion, tumorigenesis, and wound healing via stimulation of enzymes required for remodeling of the extracellular matrix
CD147, or basigin,
115
r, suggesting clinical significance; an in vitro monocyte monolayer assay also predicted clinical signficance.
anti oka
116
The antigen in the Raph system is
RAPH/MER2,
117
is encoded by the gene CD151 located on chromosome 11 at position 11p15.5.4
MER2
118
119
Three Cromer antigens
Tca, Tcb, and Tcc,
are antithetical;
120
○ is typically found in blacks and is not
found in whites.
The Cr(a–) phenotype
121
have weakened expression of all
other high-prevalence Cromer
antigens due to a markedly reduced
copy number of D
Dr(a–) RB
122
s the antibody made by
individuals with the Cromer null Inab
phenoty
Anti-IFC
123
located on complement receptor 1 (CR1) \
Knops
124
Null phenotype of knops
Helgeson phenotype
125
weakly expressed on cord RBCs and
weaken upon storage of adult RBCs (e.g.,
older units of blood)
Knops
126
difficult to adsorb and elute.
Knops
127
could play a role in Leishmania,
Legionella, and Mycobacterium
infections
CR1
128
also binds P. falciparum with rosette
formation a clinical finding associated
with severe malaria
Cr1
129
show reduced P.
falciparum binding and rosetting
St (a-) RBCs
130
these RBCs type Kn(a–b–), McC(a–),
Sl(a–), and Yk(a–) because of the low
copy number of CR1, but they are not
truly devoid of Knops antigens.
Helgeson phenotype”
131
○ is frequently found in multiply
transfused individuals and
multi-specific sera;
anti-Kna
132
Where is indian
Cd44
133
134
○ has been found in only one individual
who presented with congenital
dyserythropoietic anemia and
whose RBCs also typed Co(a–b–).
In(a–b–) phenotype
135
Carried on CD147, or basigin
Ok
136
Red cell aging is accompanied by
progressive loss of,
CD47
137
is encoded by the gene CD151
MER2
138
appears to be
essential for the assembly of
basement membranes in the kidney
and skin.
CD151
139
Tetraspanin
CD151
140
expression decreases over
time with increasing maturation of
erythroid ce
MER2
141
Those individuals who have made
anti-MER2 showed mutations in
.
CD151
142
CD151 GPI-linked glycoprotein
CD108
JMH
143
Sema7a
JMH
144
Inhibits nk cell proliferation and is a
negative regulator of t cell activation
SEMA7A
145
Stimulates chemotaxis, secretion of
inflammatory cytokines and dendritic
cell maturation in monocytes
SEMA7A
146
represents the anti gen recognized by
antibodies made by individuals lacking
the JMH protei
JMH1
147
glycerol
transporter aqua porin 3 (AQP3),
Gill
148
was shown to be intemnalized
during P. falciparum infection as part
of the parasitophorous vacuol
AQP3
149
protects against hydroxyl radicals and
osmotic stress
Aqp3
150
a decrease in is associated
with decreased skin elasticity, poor
wound healing, and eczema
AQP3
151
is observed in basal
cell carcino
increased AQP3
BB LEC
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