4 determinants of cardiac output
The number of cardiac contractions per minute. Can be affected by many variables depending on pressure.
Heart rate
increases HR by releasing norepinephrine
Positive chronotropic effect
decreases HR by releasing acetylcholine
Negative chronotropi effect
Preload
Afterload
A increased after load causes what?
Decreased stroke volume and decreased cardiac output
A decreased afterload causes what?
Increased stroke volume and increased cardiac output
Contractability
What can cause a decrease in contractability
Hypoxia or acidosis
Formula for calculating cardiac output
Heart rate X Stroke volume = Cardiac output
Normal cardiac output in a healthy adult
4-7 L/min
How does exercise or activity affect cardiac output?
Increases it
How does rest/sleep affect cardiac output
Decreases it
Labs associated with CV disease
Age related cardiovascular changes
1 cause of death in older adults
Heart disease
Altherosclerotic plaques cause what? Which increases the risk for what?
Increased fibrotic changes cause what?
HTN
List things that cause alterations in perfusion
Early menopause
Clotting disorders
confenital cardiac deffects
CAD