What surrounds the entire muscle?
Epimysium
What surrounds a fascicle?
Perimysium
What surrounds each muscle fiber?
Endomysium
What is the muscle cell membrane called?
Sarcolemma
Functional unit of the myofibril?
Sarcomere
Region containing only myosin?
H-zone
Region containing only actin?
I-band
Protein that stabilizes myosin?
Titin
Protein that blocks myosin binding site at rest?
Tropomyosin
Protein that binds Ca2+?
Troponin
Which troponin subunit binds Ca2+?
Troponin-C
Stores Ca2+ for contraction?
Sarcoplasmic reticulum
Conducts action potential into fiber?
T-tubules
Produces ATP?
Mitochondria
Define excitation–contraction coupling
Conversion of an electrical signal into a mechanical contraction
Neurotransmitter released at NMJ?
Acetylcholine (ACh)
Receptor ACh binds to?
ACh receptor on motor end plate
Ion responsible for depolarization?
Na+
Voltage sensor in T-tubule?
DHPR
Ca2+ release channel in SR?
Ryanodine receptor (RYR)
What allows cross-bridge cycling to begin?
Ca2+ binding to troponin
What enzyme pumps Ca2+ back into SR?
SERCA (Ca2+-ATPase)
Why does muscle relaxation require ATP?
ATP is needed to detach myosin and pump Ca2+ back into SR
What causes the power stroke?
Release of Pi and ADP from myosin head