What labs help differentiate bacterial vs viral infection?
CBC, platelet count, CRP, procalcitonin, ESR, cultures
How is enterovirus transmitted?
Fecal-oral, respiratory, and vertical transmission
When is enterovirus most common?
Summer and fall
Name common diseases caused by enterovirus.
Hand-foot-mouth, herpangina, pleurodynia, myocarditis, meningitis, conjunctivitis, neonatal sepsis
Classic presentation of HSV-1 gingivostomatitis?
Pharyngitis with erythematous vesicles, halitosis, lymphadenopathy
What is herpes labialis?
Clusters of vesicles that crust over, classic cold sore
Typical presentation of HSV-2 primary infection?
Vesicopustules and ulceration with edema in genital areas
How is neonatal HSV infection characterized?
Always symptomatic and severe disease
General treatment approach for HSV?
Supportive unless life-threatening
Most common cause of infectious mononucleosis?
Epstein-Barr virus (EBV)
Mode of transmission for mononucleosis?
Close personal contact, pharyngeal secretions, blood
Key diagnostic findings in mono?
CBC >10% lymphocytes, positive Monospot (80% accurate)
Cardinal symptoms of mono?
Fever, sore throat, lymphadenopathy, splenomegaly
Treatment for uncomplicated mononucleosis?
Supportive care only; avoid steroids and acyclovir
Activity restriction in mono?
Avoid contact sports and strenuous exercise
How is varicella transmitted?
Direct contact, droplets, airborne
Describe varicella rash progression.
Pruritic lesions → vesicles → crust in 24–48 hrs
When is varicella no longer contagious?
After lesions crust over
Treatment for immunocompromised varicella patients?
IV acyclovir
Major complication to monitor for in varicella?
Reye’s syndrome
Three routes of mother-to-child HIV transmission?
In utero, intrapartum, postpartum
What happens to CD4 count in HIV?
Decreases as viral load increases
Goal of HIV treatment?
Undetectable viral load
Newborn HIV prophylaxis?
Zidovudine protocol