Name the risk factors for GERD.
Increased intra-abdominal pressure (over-eating, obesity, pregnancy, ascites, heavy lifting), medications (Calcium channel blockers), smoking, hiatal hernia, delayed gastric empying
Define GERD.
Reflux of gastric contents into the esophagus due to LES incompetence ≥2x/week.
What are the diagnostic tests for GERD?
Endoscopy
Biopsy
pH monitoring
Manometry (LES pressure test)
Upper GI barium study
GI cocktail
Name two common complications of GERD.
Esophagitis
Barrett’s esophagus
Respriratory compromise
Laryngopharyngeal Reflux
What is Barrett’s esophagus and what is it caused by?
Permanent change to columnar epithelium, considered precancerous. Caused by GERD.
What is the first-line medication class for GERD?
Proton pump inhibitors (PPIs).
What medications are used to treat GERD?
PPIs
Prokinetic agents
Acid neutralizers
H2 receptor blockers
What is the most common type of hiatal hernia? Explain the condition.
Sliding hernia, where the stomach (typically the fundus) slides above the diaphragm and back down.
Which type of hiatal hernia has a higher risk of strangulation? Explain the condition.
Rolling (paraesophageal) hernia. Fundus of the stomach rolls through diaphragm and stays, forming a pocket next to the esophagus and is at risk for strangulation.
Name risk factor for hiatal hernias.
Increased abdominal pressure (ascites, obesity, pregnancy, heavy lifting, constipation)
Advanced age
Gender (more common in women
Trauma
Congenital (rare)
Name some clinical manifestations of hiatal hernias.
Belching/ regurgitation
GERD/ heartburn
Indigestion
Chest pain
Swallowing difficulty
Acidic taste
N/V
Dyspnea
Nocturnal cough/ wheeze
Name complications of hiatal hernias
Bowel obstruction
Pulmonary complications
Ulcers
Hemorrhage
Strangulation
Esophagitis
What are the diagnostic tests for hiatal hernias?
Barium series aka esophagram or Barium swallow - (x-ray the throat and esophagus)
Upper Endoscopy
pH monitoring
First-line med for hiatal hernia?
Proton pump inhibitor (PPI).
Surgical option for refractory hiatal hernia?
Nissen fundoplication (360%)
Toupet fundoplication (270%)
What is gastritis?
Inflammation of the stomach mucosa due to breakdown of protective barriers.
Name risk factors for Gastritis.
NSAIDS, ETOH, H. pylori, radiation exposure, stress conditions
Name common symptoms of gastritis.
Epigastric pain, dyspepsia, anorexia, nausea, vomiting.
What are the diagnostic tests for gastritis?
Esophagogastroduodenoscopy (EGD) with biopsy, H. pylori test, CBC (intrinsic factor), Guaiac test for occult blood
What are the treatment options for gastritis?
Eliminate cause if known
NG tube
PPIs
H2 blockers
Antacids
Abx (if caused by H. pylori)
What are the complications of gastritis?
Ulcer, hemorrhage, increased risk of stomach cancer
Name the risk factors of Peptic Ulcer Disease.
H. pylori (the major risk factor - causing 80% of gastric and 90% of duodenal ulcers)
NSAIDs (inhibit prostaglandin synthesis, increase gastric acid secretion and reduce the integrity of the mucosal barrier)
Stress
ETOH
Smoking
Genetic predisposition
Older age
Irregular/ poor diet
Gastric ulcer pain timing?
Shortly after eating (1-2 hours)
Duodenal ulcer pain timing?
2–5 hours after meals and at night.