True about malignant tumors of the kidney EXCEPT
a. can arise from any part of the nephron
b. resistance to cytotoxic agents, infrequent responses to modifiers such as IL-2
c. poor activity to antiangiogenesis targeted agents
d. usually solid, but can also be cystic
C. robust activity
Established etiology and environmental factors of RCC
HOT
Hypertension
Obessity
Tobacco exposure (#1)
Most common sites of mets in RCC
lymph nodes
lungs