UroPathogenic E.coli (UPEC)

Question 1

what is the biology of UPEC?

Answer 1

• Gram Negative Bacilli
• Lactose Fermenter
• Reduce Nitrate to Nitrite

Question 2

how is the course of the pathogenesis of UPEC?

Answer 2

Fimbriae attaches to uro-epithelial cells and biofilm is formed.

Question 3

what will cause the Pyogenic symptoms seen in UPEC?

Answer 3

are mediated by hemolysin and immune response to LPS

Question 4

where is UPEC flora normal in the body?

Answer 4

colon

Question 5

how is UPEC infection get acquired in hospitals?

Answer 5

through catheters

Question 6

how is UPEC infection get acquired in the community?

Answer 6

lack of hygiene

Question 7

how will an infection with UPEC present with?

Answer 7

• UTI/Cystitis (90% of cases)
• Low grade fever, dysuria
• Pyelonephritis
• high fever, dysuria, low flank pain

Question 8

how is an infection with UPEC diagnosed?

Answer 8

Urinalysis

Question 9

how do you treat UPEC?

Answer 9

*TMP-SMX

*Fluoroquinolones

\*Based on urinalysis Ab-R/S

Question 10

what will a UTI Urinalysis detect?

Answer 10

Nitrites