UTUC articles Flashcards by Matthew Smith

Q

UTUC lit

POUT

5

A

Peri-Op chemotherapy vs surveillance in UTuc
Adjuvant systemic Gem/Cis improved DFS over placebo after NUx for advanced nmUTUC
RCT 261 pts with M0 UTUC (N1-3)
DFS 65% vs 45%
OS 67% vs 56%
44% vs 4% AEs

Lancet Onc 2020

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Q

UTUC lit

Mitomycin-contining Reverse Thermal gel

3

A

MMC gel destroyed LG UTUC but cause stenosis in 44%
Phase 3 open label 71pts with LG UTUC with weekly retrograde Jelmyto
60% CR, 44% stenosis and 32% UTI

Lancet Onc 2020

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Q

UTUC lit

URANUS

2

A

RCT 140 pts with HR UTUC
NAC vs adjuvant chemo (Gem/Cis or MVAC)

trial ongoing

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