Uveitis

Question 1

Which 6 retinal vasculitis affect venules?

Answer 1

1. Sarcoid
2. MS
3. Birdshot
4. Eales
5. Bechets
6. HIV paraviral syndrome

Question 2

Which 7 retinal vasculitis affect arterioles?

Answer 2

1. SLE
2. PAN
3. Necrotizing herpetic retinitis (ARN)
4. Syphilis
5. VZV (PORN)
6. IRVAN
7. Churg-Strauss syndrome

Question 3

Which 2 bugs are the cause of late bleb associated endophthalmitis?

Answer 3

1. H flu

2. Strep

Question 4

Granular CMV retinitis occurs where?

Answer 4

Peripherally

Question 5

What are 3 types of polymorphonuclear leukocytes?

Answer 5

1. Neutrophils - most abundant granulocytes in the blood
2. Eosinophils - IL-5 most impt mediator
3. Basophil / mast cell

Question 6

What are the steps of the immune response arc?

Answer 6

1. Afferent
2. Processing
3. Effector

Question 7

What is type V hypersensitivity?

Answer 7

Stimulatory

Question 8

CAR is seen in what 2 dx?

Answer 8

1. Small cell lung CA

2. Cutaneous melanoma

Question 9

What is the outer layer of zonal inflm?

Answer 9

Fibrotic reparative or granulation tissue infiltrated with NONgranulomatous inflm and plasma cells, presumably secreting specific Antibodies.

Question 10

What causes an eosinophilic granuloma in the eye?

Answer 10

Toxocara granuloma (strong Th2 response)

Question 11

Which anterior uveitis has moderate severity (red, painful) that has a poor response to steroids?

Answer 11

Syphilis

Question 12

Is vitiritis present in serpiginous choroidopathy?

Answer 12

NO

Question 13

Which 5 Posterior Uveitis with Arteritis and Phlebitis?

Answer 13

1. Toxoplasmosis
2. Relapsing polychondritis
3. Wegener granulomatosis
4. Crohn dx
5. FROSTED BRANCH ANGITIS

Question 14

Which cell is the predominant inflm cell in the eye in uveitis?

Answer 14

lymphocytes

Question 15

When are 3 instances when corticosteriods are not indicated?

Answer 15

1. Fuchs heterochromic iridocyclitis
2. Pars planitis WITHOUT CME
   * 3. peripheral lesions in toxoplasmosis not affecting optic disc or macula**

Question 16

Recurrent anterior nongraunulomatous uveitis is what?

Answer 16

HLA-B27 - DDx

1. Ankylosing spondylitis
2. Reiter syndrome (reactive arthritis)
3. Inflm bowel dz
4. Psoriatic arthritis
5. postinfectious, or reactive, arthritis

Question 17

Pulmonary apical fibrosis and aortitis that is a/w aortic valve insufficiency are complications of what?

Answer 17

Ankylosing spondylitis

Question 18

What is the most common eye lesion in Reiter syndrome?

Answer 18

Conjunctivitis - mucopurlent and papillary

Question 19

What 4 drugs cause uveitis?

Answer 19

1. Rifabutin
2. biphosphanates
3. sulfonamides
4. diethylcarbamazine (an antifilarial agent)
5. oral contraceptives

Question 20

What is the tx for Fuch’s heterochromic iridocyclitis?

Answer 20

Topical steriods BUT not aggressive tx because inflm persists for decades with good prognosis.

Question 21

HLA-DR15?

Answer 21

Multiple sclerosis

Question 22

HLA-DR15 and HLA-DR51?

Answer 22

Pars planitis

Question 23

What are the 4 tx steps for Pars planitis?

Answer 23

1. Periocular steriods
2. Peripheral ablation - PRP / cryo
3. PPV, EL
4. Systemic immunomodulatory agents

Question 24

Hep B as a causitive factor with hypertensive retinopathy, cranial nerve palsy, Horners is caused by what?

Answer 24

Polyarteritis nodosa

Question 25

Which surgery is the main risk for developing SO?

Answer 25

PPV

Question 26

How do PIC and MFC differ on FA?

Answer 26

Early hyperflurorescence in PIC; both have late staining. (MFC has early blockage)

Question 27

What type of inflm is seen in Bechets?

Answer 27

NONgranulomatous

Question 28

Which 3 d/o do u see stellate KP - diffuse corneal distribution?

Answer 28

1. Fuch's heterochromic iridocyclitis 2. CMV 3. Toxoplasmosis

Question 29

What are the 3 presentation of CMV-R?

Answer 29

1. Classic or fulminant retinitis, typically appearing in the PP 2. Granular or indolent - found more in the periphery 3. Perivascular - similar to frosted branch angitis

Question 30

Migratory arthritis in white males with CN palsys with less than 5% of cases having b/l panuvetis and vasculitis is what?

Answer 30

Whipple dx. Tx with Bactrim

Question 31

A hypopyon occuring in the subretinal or subhyloidal space with hemorrhage in all retinal layers occurs in what?

Answer 31

Aspergillus endophthalmitis

Question 32

What 3 d/o present with a pseudohypopyon?

Answer 32

1. Bechets 2. Leukemia 3. Retinoblastoma

Question 33

CWS with a lesion size over 750um is suggestive of what?

Answer 33

Very early CMV retinitis

Question 34

Cidofovir 2SE are what?

Answer 34

1. Hypotony | 2. Anterior uveitis (immune reconstitution uveitis)

Question 35

HLA-B7/ HLA-DR2?

Answer 35

POHS

Question 36

Cyclosporine / Tacrolimus SE and mechanism?

Answer 36

Nephrotoxicity; T cell signaling

Question 37

Sjogren's causes what type of uveitis?

Answer 37

Intermediate

Question 38

Ig not in tears?

Answer 38

IgD

Question 39

Which drug is the best at treating Bechets?

Answer 39

Chlorambucil

Question 40

When should a steroid sparing agent be used when what level of steriod has been exceeded for a day?

Answer 40

10mg

Question 41

What cause drug induced lupus?

Answer 41

Inflixamab

Question 42

Which uveitis has an initial increase in IOP?

Answer 42

HERPETIC!!

Question 43

Bechcets is HLA?

Answer 43

B51

Question 44

Which dz has life threatening laryngeal inflm?

Answer 44

Relapsing polychondritis

Question 45

Keratoderma blennorrhagicum is what and seen in what?

Answer 45

1. Skin lesions on the palms and soles of feet | 2. REITER's syndrome