Valentovic

Question 1

Cholestyramine, colesevelam, and colestipol

Answer 1

Bile acid resins

Question 2

Lowers ONLY cholesterol

Answer 2

Bile acid resins

Question 3

Enhance hepatic conversion of cholesterol to bile acids

Answer 3

Bile acid resins

Question 4

Bile acids have negative feedback on _________, rate limiting enzyme

Answer 4

7alpha-hydroxylase

Question 5

Bile acid resins ______ # of hepatic LDL receptors

Answer 5

Increase

Question 6

Bile acid resins _______ form must be mixed with liquids and taken with a meal

Answer 6

Powder

Question 7

GI side effects most common. Interfere with absorption of fat soluble vitamins and/or drugs. Other drugs must be taken 1 hour before or 4 hours after

Answer 7

Bile acid resin

Question 8

Bile acid resins ____ be used during pregnancy. Safe in children ___ or older

Answer 8

Can

6

Question 9

HMG CoA reductase inhibitors are known as

Answer 9

Statins

Question 10

Statins are ___________ inhibitors and they _____ hepatic LDL receptors

Answer 10

Competitive

Increase

Question 11

All statins lower ______

Atorvastatin and Rosuvastatin also lower _________

Answer 11

Cholesterol

Triglycerides

Question 12

Adversely elevates serum transaminases. Causes muscle weakness, myalgias, and dark brown urine. Associated with elevated CPK

Answer 12

Statins

Question 13

Statins ____ be used in pregnancy/nursing mothers

Answer 13

Cannot

Question 14

Rosuvastatin and Atorvastatin have longest ____ and can be taken at any time of day

Answer 14

Half life

Question 15

Maximum endogenous cholesterol synthesis occurs at

Answer 15

Night

Question 16

Fluvastatin, Lovastatin, and simvastatin have ______ and have to be taken at night

Answer 16

Short

Question 17

All statins can be used after _____ years, pravastatin can be used after ______ yrs

Answer 17

10

8

Question 18

____ increases Lovastatin absorption

Answer 18

Food

Question 19

Food _______ absorption of pravastatin and pitavastatin

Answer 19

Decrease

Question 20

Hyperlipidemia
Chol >
LDL >
Triglycerides >

Answer 20

240
160
200

Question 21

Lovastatin and simvastatin are

Answer 21

Prodrugs

Question 22

Rosuvastatin and fluvastatin

Answer 22

CYP2C9

Question 23

Atorvastatin, Lovastatin, and Simvastatin. Avoid grapefruit

Answer 23

CYP 3A4

Question 24

Inhibits cholesterol absorption at enterocytes of small intestine.

Answer 24

Ezetimibe

Question 25

Reduces cholesterol. When combined with statins, will lower LDL more than high dose statin

Answer 25

Ezetimibe

Question 26

Alirocumab and evolocumab are

Answer 26

PCSK9 inhibitors | Proprotein convert are subtilisin/Kexin 9

Question 27

Lovastatin and simvastatin are

Answer 27

Prodrugs

Question 28

Rosuvastatin and fluvastatin

Answer 28

CYP2C9

Question 29

Atorvastatin, Lovastatin, and Simvastatin. Avoid grapefruit

Answer 29

CYP 3A4

Question 30

Inhibits cholesterol absorption at enterocytes of small intestine.

Answer 30

Ezetimibe

Question 31

Reduces cholesterol. When combined with statins, will lower LDL more than high dose statin

Answer 31

Ezetimibe

Question 32

Alirocumab and evolocumab are

Answer 32

PCSK9 inhibitors | Proprotein convert are subtilisin/Kexin 9