Vancomycin

Question 1

Vancomycin MOA

Answer 1

Binds d Ala d ala. not susceptible to beta lactamases

Question 2

Vancomycin use

Answer 2

GP only

MRSA, C diff (oral)

Question 3

Vancomycin AE

Answer 3

Nephrotoxicity
Ototoxicity
Thrombophlebitis

RED MAN SYNDROME- flushing, erythema, itching upper body, face, neck dt direct activation of mast cells and histamine release

Preventable by pretreatment with antihistamines and slow infusion

Question 4

Vancomycin resistance

Answer 4

Bacteria change amino acids from d ala d ala to D ALA D LAC- vancomycin cannot bind