Vasculitis

Question 1

Vasculitis Pathogenic mechanisms has 2 forms

Answer 1

• Immune-mediated inflammation
• Direct vascular invasion by infectious
  pathogens.

Question 2

Immunosuppressive therapy can be function for which type of vasculitis

Answer 2

immune mediated vasculitis

Question 3

Immune-mediated Vasculitis types

Answer 3

• circulating Immune complex deposition: SLE
• attacks endothelium
• Antineutrophil cytoplasmic antibodies (ANCA)
  ( antibodies directed against cytoplasmic constituents of neutrophils)
• Anti-endothelial cell antibodies: Kawasaki
  disease
• Autoreactive T cells
  *T cells directed against normal antigen

Question 4

Wegener granulomatosis disease is associated with type of immune mediated vasculitis

Answer 4

• Antineutrophil cytoplasmic antibodies (ANCA)
• Antiproteinase-3 (PR3-
  ANCA), c- ANCA:

Question 5

What’s is PR3

Answer 5

neutrophil
azurophilic granule
constituent