Vasculitis

Question 1

What is the most common form of systemic vasculitis in adults?

Answer 1

Giant cell (Temporal) Arteritis - painful temporal artery 
Transmural inflammation - multi-nucleated giant cells

Question 2

Takayasu arteritis affects what arteries and which populations?

Answer 2

Pulmonary arteries 50% - large

Japanese women

Question 3

What two types of vasculitis affect the medium sized vessels?

Answer 3

1. Polyarteritis Nodosa

2. Kawasaki Syndrome

Question 4

What are characteristics of polyarteritis nodosa?

Answer 4

1. Renal and visceral arteries (spares lungs)
2. All stages of inflamm/fibrosis exist
3. Young adults - 30% Hep B Ag+
4. Necrosis w/ karyorrhexis

Question 5

What is Kawasaki Syndrome

Answer 5

1. Often coronary arteries w/ aneurysm
2. 80% <4 yo in Japan
3. Aneurysms

Question 6

What types of vasculitis affect small vessels?

Answer 6

1. Microscopic polyangiitis (leukoclastic vasculitis)
2. Wegener Granulomatosis
3. Churg-Strauss Syndrome (allergic granulomatosis & angiitis)
4. Thromboangiitis Obliterans (Buerger disease)
5. Raynaud

Question 7

Which type of vasculitis is MPO-ANCA+

Answer 7

Microscopic Polyangiitis

Question 8

Which type of vasculitis is PR3-ANCA+

Answer 8

Wegener Granulomatosis