Vasculitis

Question 1

what is it?

Answer 1

inflammation of blood vessels

Question 2

example

Answer 2

churg-strauss syndrome

Question 3

what is churg-strauss syndrome?

Answer 3

eosinophilic granulomatosis with polyangiitis

Question 4

presentation of churg-strauss syndrome

Answer 4

epistaxis
inflamed lungs
haematuria 
varied presentation 
purpuric rash
peripheral neuropathy 
pericarditis 
myocarditis 
glomerulonephritis

Question 5

what causes the symptoms of churg-strauss syndrome

Answer 5

abnormal accumulation of large number of antibodies
increased eosinophils
causing inflammatory and allergic response
directly causing inflammation of veins and small and medium-sized arteries

Question 6

clinical features

Answer 6

epistaxis 
haematuria
fatigue
widespread wheeze
raised RR and HR
purpuric rash - non-blanching

Question 7

investigations

Answer 7

FBC
CXR
ECG
CRP
bloods 
U&Es 
VBG
p-ANCA antibodies

Question 8

how to manage asthma acutely?

Answer 8

oxygen 
salbutamol
hydrocortisone
ipratropium bromide 
prednisolone
consider magnesium sulphate 
if tiring and signs of life-threatening asthma contact ITU

Question 9

blood results

Answer 9

raised CRP
low Hb
raised eosinophils

Question 10

CXR results

Answer 10

patchy opacification of both lungs - inflammation

Question 11

management

Answer 11

treat presentation

steroids