Disease, Vector and Locale: Rickettsie rickettsii
- RMSF (no eschar)
- Dermacentor wood tick
- North and South America
Disease, Vector and Locale: Ricketssia akari
- Rickettsial pox
- Mite bite from a house mouse + eschar (scab lesion)
- USA, USSR, Korea, Africa
Disease, Vector and Locale: Rickettsia africae
- African tick fever, eschar
- Tick
- Africa
Disease, Vector and Locale:** Rickettsia prowazekii**
- Epidemic Typhus (no eschar)
- Louse
- World wide
Disease, Vector and Locale: Rickettsia typhi
- Murine typhus
- Flea (ty-phee)
- World Wide
Disease, Vector and Locale: O. tsutsumagushi
- Typhus (no eschar)
- human mite (chigger)
- South East Asia
Disease, Vector and Locale: Coxiella burnetti
- Q fever
- no vector
- no locale
What is Rocky Mounted Spotted Fever pathogenesis?
- attach to vascular endothelium
- phagocytized
- reproduce within endothelium
- spread into nearby cells
- Focal vasculitis
- fluid loss
- perfusion difficulties (can lead to gangrene)
What is treatment for RMSF?
- Doxycycline
- Chloramphenicol (as second choice)
RMSF is (centripetal/centrifugal)
Centripetal (wrists, ankles –> trunk)
from R. rickettsii- think of the rock climbing!
What are the two typhus-group rickettsia?
- R. prowezekii
- R. typhi
R. prowazekii is (centripetal/centrifugal)
Centrifugal (from trunk–>extremities, sparing palsm and soles and face)
(think of football game!)
Clinical illness and transmission for R. typhi
tranmission: rat flea (reservoir is rat or cat)
Clinical illness: abrupt fever, HA, half have rash of chest and abdomen, extremities spared
O. tsutsumagushi is (centrifugal/centripetal) spread
Centrifugal
3 important characteristics of Ehrlichia and Anaplasma
- obligate intracellular organisms
- parasitize white blood cells
- tick transmission (summer-time illnesses)
What are the 4 Ehrlichial Diseases and what do they infect?
- Sennetsu Fever (infectious mono like)
- Human Monocyte Ehrlichiosis (infects blood monocytes
- Human Granulocyte Anaplasmosis (infects blood granulocytes)
- E. minnesota
Which two organisms are associated with Human Monocyte Ehrlichiosis (HME)?
- Anaplasma phagocytophilum
- E. chaffeensis
What is the reservoir and vector for E. ewingii?
causes HGA
Reservoir: dogs
Vector: Lone star tick
What is the vector for E. chafeensis?
Lone-star tick
What is the reservoir and vector associated with Human granulocytic ehrlichiosis?
Reservoir: small mammals (mice, chipmunks, voles)
Vector: Ixodes scapularis (deer tick)
Q fever from ____ is usually self-limiting, so you dont need antibiotics. If conditions become more serious (pneumonia, hepatitis, endocarditis, granuloma formation in liver), then treat with ____
- Coxiella burnetti
- Tetracycline
What is the vector for Chlamydia?
No vector- transmitted host to host
Treatment of choice for Chlamydia:
Azithromycin (macrolide)
alternatives: Tetracycline, or Erythromycin in Pregnancy
Ixodes scapularis tick is involved in the tranmission of these three diseases:
- borrelia (lyme)
- anaplasmosis
- babesiosis (protozoal)- fever and hemolytic anemia, have butterfly look in blood smear
