What is the tidal volume target for ARDS patients on a ventilator?
4–6 mL/kg of ideal body weight
Why use low tidal volumes in ARDS?
To prevent barotrauma and volutrauma from alveolar overdistension
What plateau pressure should be maintained in ARDS?
≤ 30 cm H₂O
What is the initial ventilator mode for ARDS?
Volume Assist-Control (AC-VC)
What is the minimum acceptable pH in permissive hypercapnia for ARDS?
7.15
If plateau pressure is >30 cm H₂O, what should be done?
Reduce tidal volume by 1 mL/kg (down to minimum of 4 mL/kg)
What FiO₂ should you aim for once oxygenation improves in ARDS?
Titrate FiO₂ to < 60% if possible while maintaining SpO₂ > 88%
What PEEP should be used in ARDS?
Use the PEEP/FiO₂ ARDSnet table
When should prone positioning be considered in ARDS?
When PaO₂/FiO₂ < 150 despite optimized vent settings
When should neuromuscular blockade be used in ARDS?
If patient is ventilator asynchronous or severely hypoxic despite max support
What PaO₂/FiO₂ ratio defines severe ARDS?
< 100 mmHg
What are the oxygenation goals for ARDS?
PaO₂ 55–80 mmHg or SpO₂ 88–95%
Why do we tolerate high PaCO₂ in ARDS (‘permissive hypercapnia’)?
To avoid lung injury from high tidal volumes